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ForumsLab Results & BiomarkersSHBG changes during weight loss on GLP-1 — my results so far Page 2

SHBG changes during weight loss on GLP-1 — my results so far

tampaLisa73 Mon, Jun 23, 2025 at 7:38 AM 45 replies 1,803 viewsPage 2 of 9
RunnerRach
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Jun 23, 2025 at 10:28 AM#6

The sleep piece resonates hard with me. I'm a nurse doing 12-hour night shifts and my weight loss has been slower than most people I see posting here. I average about 5 hours of broken sleep on work days. I wonder how much that's holding me back.

47 22BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 44 others
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Dr.CardioMD
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Cleveland, OH
Jun 23, 2025 at 10:45 AM#7

Sleep deprivation is enormously underappreciated as a factor in weight management. There are studies showing that people in a caloric deficit who sleep 5.5 hours lose 55% less fat and 60% more lean mass compared to those sleeping 8.5 hours — same caloric intake. Shift workers consistently show higher rates of obesity, metabolic syndrome, and cardiovascular disease, and disrupted circadian rhythm is a major contributor.

I know you can't always control your schedule, but even small improvements — blackout curtains, consistent wake times on days off, limiting caffeine 8+ hours before sleep — can help.

Last edited: Jun 23, 2025 at 4:45 PM
43 4Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 40 others
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dave_SLC
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Aug 2024
Salt Lake City, UT
Jun 23, 2025 at 11:02 AM#8

Looking at the OP's numbers from a trends perspective: the "plateau" from week 14-19 actually shows a slight downward trend if you plot it. 222 → 219 over 5 weeks is about 0.6 lbs/week. That's not zero — it's just much slower than the 2.3-3.0 lbs/week she was losing before.

Psychologically, going from 3 lbs/week to 0.6 lbs/week feels like a plateau even though progress is technically still happening. This is why I always recommend plotting a 7-day moving average rather than looking at individual weigh-ins. Daily weight fluctuations of 2-4 lbs are completely normal due to water, sodium, and digestive contents.

39 11james_edin, FranDenver, Dr.BariatricHTX and 36 others
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