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Tagging this for the weekly digest. 👍
Slightly tangential to GCG receptor signaling but PurityPaulOR reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
Dr.EndoIndy said:Follow-up question: how long did you wait before increasing your dose
This is exactly right. Dr.EndoIndy articulated what I have been trying to explain to my doctor for months. The GCG receptor signaling aspect is the most important factor.
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Adding my data to this GCG receptor signaling discussion:
| Metric | Baseline | Month 3 | Month 8 |
|---|---|---|---|
| Weight | 266 lbs | 226 lbs | 201 lbs |
| A1C | 7.0% | 5.8% | 5.4% |
| hsCRP | 5.0 | 2.0 | 0.8 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.