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Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsRetatrutide cholesterol effects — looking for input Page 3

Retatrutide cholesterol effects — looking for input

jennifer_SEA Fri, Sep 26, 2025 at 4:43 PM 15 replies 1,091 viewsPage 3 of 3
MikeKY_noInsulin
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Oct 2024
Louisville, KY
Sep 26, 2025 at 8:58 PM#11

carlos_SATX — wow. This community is amazing.

Last edited: Sep 26, 2025 at 11:58 PM
26 1sean_dublin, hannah_MT, Dr.SportsMedIN and 23 others
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emily_PDX
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Nov 2024
Portland, OR
Sep 26, 2025 at 9:15 PM#12

Slightly tangential to Retatrutide cholesterol but jennifer_SEA reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

16 20PharmD_Rodriguez, julia.endo, JessicaM_2024 and 13 others
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andrew_nyc
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Apr 2024
New York, NY
Sep 26, 2025 at 9:32 PM#13

Thanks for sharing this, jennifer_SEA. A few questions about your Retatrutide experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Retatrutide?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Sep 27, 2025 at 2:32 AM
26 3PharmD_Rodriguez, julia.endo, JessicaM_2024 and 23 others
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jennifer_SEA
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Nov 2024
Seattle, WA
Sep 26, 2025 at 9:49 PM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Retatrutide cholesterol.

To answer emily_PDX: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

3 20jim_asheville, matt_MKE, Dr.ReproEndo
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dave_SLC
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Aug 2024
Salt Lake City, UT
Sep 26, 2025 at 10:06 PM#15

Relevant to Retatrutide cholesterol — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 197 → 97 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

50 7Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 47 others
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