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ForumsLab Results & BiomarkersUric acid trends on GLP-1 — looking for input

Uric acid trends on GLP-1 — looking for input

FDA_TrackerJim Thu, May 29, 2025 at 11:15 AM 15 replies 1,538 viewsPage 1 of 3
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FDA_TrackerJim
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May 29, 2025 at 12:40 PM#1

Hey everyone. I have been on semaglutide for 3 months now and wanted to get the community's take on something.

Uric acid trends on GLP-1 — looking for input

I have been reading through old threads but have not found exactly what I'm looking for. My situation: my doctor suggested uric acid trends on glp-1 looking and I am not sure what to make of it.

Has anyone else dealt with this? What was your experience? My endo was not super helpful — just said to "monitor it" which is not exactly actionable advice lol.

Any input appreciated. Thanks in advance. 🙏

35 5Dr.Martinez, mike_mod, SarahChen_PharmD and 32 others
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RetaRick_CA
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California
May 29, 2025 at 12:57 PM#2

Uric acid trends on GLP-1 looking for — I actually dealt with this exact situation around month 3.

Short answer: talk to your prescriber first. Longer answer: I wrote about my experience in the results forum if you want the full details.

Last edited: May 29, 2025 at 1:57 PM
44 10AmyNC_wife, SkepticalSean, Dr.CardioMD and 41 others
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GenomicsKate
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Oct 2024
Cambridge, MA
May 29, 2025 at 1:14 PM#3
RetaRick_CA said:
Short answer: talk to your prescriber first

Completely agree with RetaRick_CA. I would add that Uric acid trends on GLP-1 also has implications for body composition that sometimes get overlooked in these discussions.

In my case, following a similar approach led to fewer side effects compared to what I was doing before.

Last edited: May 29, 2025 at 6:14 PM
12 1MarkLI_maint, Dr.PeteFamMed, claudia_zurich and 9 others
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traveltech_sara
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May 29, 2025 at 1:31 PM#4

Can confirm — identical experience.

Last edited: May 29, 2025 at 4:31 PM
24 14NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 21 others
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Dr.NutriCornell
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Mar 2024
Ithaca, NY
May 29, 2025 at 1:48 PM#5

As a healthcare provider, I want to add some clinical context to this discussion on Uric acid trends on GLP-1 looking for.

Building on what FDA_TrackerJim said — the evidence base here is well-established. The key publications to reference are from the STEP program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
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