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ForumsRetatrutide & Triple AgonistsTriple agonist side effect profile — what worked for you?

Triple agonist side effect profile — what worked for you?

Dr.BariatricHTX Sat, Aug 30, 2025 at 6:51 PM 12 replies 1,209 viewsPage 1 of 3
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Dr.BariatricHTX
Senior Member
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Feb 2024
Houston, TX
Aug 30, 2025 at 8:16 PM#1

My endo and I disagree about triple agonist side effect profile what and I want a reality check.

They are saying that I do not need to worry about it but everything I have read here suggests otherwise.

I trust this community's collective knowledge but I also do not want to go against medical advice without good reason. What would you do?

8 17CarlaRPh_TPA, steph_laguna, fiona_glasgow and 5 others
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PharmD_Rodriguez
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Jan 2024
Miami, FL
Aug 30, 2025 at 8:33 PM#2

Dr.BariatricHTX's experience with Triple agonist side resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 46 lbs in 11 months.

One thing I would add that Dr.BariatricHTX did not mention: the mental health improvements were just as significant.

20 7TinaHashiRN, robert_kc, dan_philly and 17 others
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wanda_boise
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Aug 2024
Boise, ID
Aug 30, 2025 at 8:50 PM#3

Thanks for sharing this, Dr.BariatricHTX. A few questions about your Triple agonist side experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about Triple agonist?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Aug 31, 2025 at 1:50 AM
32 12pam_columbus, nick_SD_fit, ben_calgary and 29 others
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Dr.BariatricHTX
Senior Member
1,456
7,234
Feb 2024
Houston, TX
Aug 30, 2025 at 9:07 PM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Triple agonist side.

To answer wanda_boise: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Aug 31, 2025 at 3:07 AM
3 1stefan_berlin, Dr.EM_Chicago, pete_RVA
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jason_paloalto
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Nov 2024
Palo Alto, CA
Aug 30, 2025 at 9:24 PM#5

Relevant to Triple agonist side effect — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 219 → 119 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

37 13Dr.EndoEP, GraceAZ_72, carl_compliance and 34 others
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