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ForumsRetatrutide & Triple AgonistsTriple agonist sounds scary - is it actually safe — looking for input Page 3

Triple agonist sounds scary - is it actually safe — looking for input

Dr.PulmRoch Fri, Aug 1, 2025 at 9:12 PM 12 replies 1,132 viewsPage 3 of 3
MariaRD
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Jun 2024
New Mexico
Aug 2, 2025 at 1:27 AM#11

amy_econ_NJ — wow. This community is amazing.

Last edited: Aug 2, 2025 at 2:27 AM
48 10Dr.NutriCornell, pam_stl, wei_SG and 45 others
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JakeSmashed95
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Aug 2024
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Aug 2, 2025 at 1:44 AM#12

Slightly tangential to Triple agonist sounds but Dr.PulmRoch reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

26 11kevin_tulsa, Dr.PainCLE, mike_mealprep and 23 others
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JakeBK_lifts
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Jul 2024
Brooklyn, NY
Aug 2, 2025 at 2:01 AM#13

Thanks for sharing this, Dr.PulmRoch. A few questions about your Triple agonist experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Triple agonist?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Aug 2, 2025 at 4:01 AM
48 24LabKate, kate.chem, DataDave and 45 others
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Dr.PulmRoch
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Jun 2024
Rochester, MN
Aug 2, 2025 at 2:18 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Triple agonist sounds.

To answer JakeSmashed95: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

30 11DebRD_ATL, KristenIndy, MarkLI_maint and 27 others
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anders_CPH
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Feb 2024
Copenhagen, DK
Aug 2, 2025 at 2:35 AM#15

Relevant to Triple agonist sounds scary - — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

3 12ChrisMacros, KetoKyle, CanadaChris
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