SkepticalSean's experience with Glucagon-mediated resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.
The main difference: I had more GI issues initially. But the overall trajectory has been remarkably similar. Down 37 lbs in 12 months.
One thing I would add that SkepticalSean did not mention: insurance coverage was a major hurdle.
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I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.
For this specific question, I would recommend: getting comprehensive baseline labs first.
Yep. My endo said the same thing about Glucagon-mediated.