Everything A1cChaser said is correct. I'd also note that A1c has some known limitations: - Iron deficiency can falsely elevate A1c - Recent blood loss or transfusion can falsely lower it - Hemoglobin variants (common in certain ethnic groups) can skew results - Kidney disease affects red blood cell turnover and A1c accuracy For prediabetic patients on GLP-1 therapy, I often find fasting insulin and HOMA-IR more sensitive early markers of improvement than A1c. If your fasting glucose dropped, your insulin sensitivity is improving. The A1c will follow. Also — congratulations to everyone in this thread. These numbers represent real metabolic healing.

Here's my data because I'm obsessed with tracking everything: Tirzepatide, titrated to 15 mg weekly | Timepoint | A1c | FBG | Fasting Insulin | HOMA-IR | |-----------|-----|-----|----------------|---------| | Baseline | 8.4% | 162 | 34.2 µIU/mL | 13.66 | | Month 2 | 7.6% | 138 | 24.1 | 8.20 | | Month 4 | 6.6% | 112 | 14.8 | 4.09 | | Month 6 | 5.8% | 94 | 9.2 | 2.13 | | Month 9 | 5.3% | 88 | 7.1 | 1.54 | The HOMA-IR trajectory is what really tells the story. I went from severe insulin resistance to basically normal. My endo showed this chart to her residents as a teaching case. 😊

I'll be honest — I was one of those "just eat less and exercise" people until I got diagnosed myself. Humble pie tastes terrible. Semaglutide 2.4 mg (Wegovy) | Timepoint | A1c | |-----------|-----| | Baseline | 6.7% | | 6 months | 5.4% | That's it. Two data points. But going from prediabetic/early T2D to solidly normal in 6 months changed my entire worldview about metabolic disease. This is powerful medicine.

Coming back to say thank you all for talking me off the ledge. I talked to my doctor and she agreed to add fasting insulin to my next panel. She also said my post-meal glucose readings on my Libre have been trending way down even if A1c hasn't moved yet. Feeling much better about things.

That's the spirit Carl! And everyone — keep dropping your numbers in this thread. The more data we collect as a community, the more useful this becomes for people researching GLP-1 therapy. Every data point matters. Let's normalize sharing lab results (while keeping it clear we're not giving medical advice, just sharing experiences). 🔬