OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on SHBG changes during.

To answer TirzTom: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

TirzTom — that is really helpful context on SHBG changes during. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Reading this thread on SHBG changes during hits close to home. Night shift nurse — I started at 271 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 46 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about SHBG changes during — take the leap. It was the best health decision I have ever made. ❤️

TirzTom — that is really helpful context on SHBG changes during. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Reading this thread on SHBG changes during hits close to home. Dad of 2 checking in — I started at 293 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 68 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about SHBG changes during — take the leap. It was the best health decision I have ever made. ❤️