Congrats carl_compliance!! Keep going — you're doing incredible. 🎉
TirzTom's experience with SHBG changes during resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.
The main difference: I had more GI issues initially. But the overall trajectory has been remarkably similar. Down 45 lbs in 10 months.
One thing I would add that TirzTom did not mention: insurance coverage was a major hurdle.
Bookmarked 📌 The SHBG changes during info in this thread is essential. Coming back to this for sure.
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Shop Reference StandardsClinical perspective on SHBG changes during weight loss on GLP-1:
I have managed over 200 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.
For this specific question, I would recommend: getting comprehensive baseline labs first.
Subscribing to this thread. SHBG changes during is exactly what I've been researching. 🙏