Reading this thread on SHBG changes during hits close to home. Night shift nurse — I started at 279 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 54 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about SHBG changes during — take the leap. It was the best health decision I have ever made. ❤️

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Relevant to SHBG changes during weight — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 231 → 101 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Thank you wanda_boise! This is incredibly helpful. Bookmarking for later. 🙏

+1 to stefan_berlin. Especially the point about "SHBG changes during is exactly what I've..." — I have seen the same in my own experience with SHBG changes during.