Reading this thread on Glucagon-mediated hits close to home. Dad of 2 checking in — I started at 277 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 52 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Glucagon-mediated — take the leap. It was the best health decision I have ever made. ❤️

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

Relevant to Glucagon-mediated — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 249 → 119 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Thank you Dr.MetabolicMD! This is incredibly helpful. Taking this to my next appointment. 🙏

+1 to tampaLisa73. Especially the point about "Glucagon-mediated is exactly what I've b..." — I have seen the same in my own experience with Glucagon-mediated.