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Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsGCG receptor signaling deep dive — looking for input Page 3

GCG receptor signaling deep dive — looking for input

VanRx_Mike Mon, Nov 27, 2023 at 5:31 AM 20 replies 2,393 viewsPage 3 of 4
mel_PDX
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Dec 2024
Portland, OR
Nov 27, 2023 at 9:46 AM#11

DataDave — wow. This community is amazing.

37 8Dr.NateNeph, PharmD_Rodriguez, julia.endo and 34 others
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NurseAsh_DET
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Sep 2024
Detroit, MI
Nov 27, 2023 at 10:03 AM#12

Slightly tangential to GCG receptor signaling but VanRx_Mike reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Nov 27, 2023 at 4:03 PM
43 14ricardo_MIA, BrianDallas92, labquiet_amy and 40 others
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zoe_NC
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Nov 2024
Charlotte, NC
Nov 27, 2023 at 10:20 AM#13

Thanks for sharing this, VanRx_Mike. A few questions about your GCG receptor experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about GCG receptor?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

45 20james_edin, FranDenver, Dr.BariatricHTX and 42 others
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VanRx_Mike
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May 2024
Vancouver, CA
Nov 27, 2023 at 10:37 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GCG receptor signaling.

To answer NurseAsh_DET: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Nov 27, 2023 at 1:37 PM
4 7Dr.Martinez, mike_mod, SarahChen_PharmD and 1 other
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HPLC_Greg
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Research Triangle, NC
Nov 27, 2023 at 10:54 AM#15

Relevant to GCG receptor signaling deep — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 201 → 101 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

37 3SaraMom3, Dr.MetabolicMD, RetaRick_CA and 34 others
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