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Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsGCG receptor signaling deep dive — looking for input Page 4

GCG receptor signaling deep dive — looking for input

VanRx_Mike Mon, Nov 27, 2023 at 5:31 AM 20 replies 2,393 viewsPage 4 of 4
KevinCompounds
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Nov 27, 2023 at 11:11 AM#16

Congrats zoe_NC!! You should be so proud of yourself. 🎉 👏

49 18jennifer_SEA, tyler_CSCS, VanRx_Mike and 46 others
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RickReta_CO
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Nov 27, 2023 at 11:28 AM#17

VanRx_Mike's experience with GCG receptor signaling resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I am on a different medication. But the overall trajectory has been remarkably similar. Down 63 lbs in 8 months.

One thing I would add that VanRx_Mike did not mention: my sleep quality improved dramatically.

8 7jim_asheville, matt_MKE, Dr.ReproEndo and 5 others
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PharmD_Rodriguez
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Nov 27, 2023 at 11:45 AM#18

Bookmarked 📌 The GCG receptor info in this thread is essential. Coming back to this for sure.

Last edited: Nov 27, 2023 at 4:45 PM
17 5robert_kc, dan_philly, MeganSA_TX and 14 others
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hans_munich
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Nov 27, 2023 at 12:02 PM#19

Clinical perspective on GCG receptor signaling deep dive :

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

Last edited: Nov 27, 2023 at 6:02 PM
4 22tammy_FL, Dr.LipidDallas, alex_tucson and 1 other
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matt_MKE
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Nov 27, 2023 at 12:19 PM#20

100%. My provider said the same thing about GCG receptor.

47 24DanielChem_CHI, marco_milano, pam_columbus and 44 others
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