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ForumsSemaglutide (Ozempic / Wegovy)Semaglutide and MASH — liver histology improvement data Page 5

Semaglutide and MASH — liver histology improvement data

MASHdoc_SA Sun, Mar 8, 2026 at 8:46 AM 22 replies 524 viewsPage 5 of 5
tammy_FL
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Mar 8, 2026 at 3:51 PM#21

MaxMetOK — that is really helpful context on Semaglutide and MASH . Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

47 11Dr.LipidDallas, alex_tucson, kevin_tulsa and 44 others
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Dr.RaviCardio
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Mar 8, 2026 at 4:08 PM#22

To answer sean_dublin's question specifically:

From a clinical standpoint, Semaglutide and MASH liver is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

49 6anna.melb_AU, mark_tokyo, hans_munich and 46 others
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MounjBrad
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Mar 8, 2026 at 4:25 PM#23

Thank you tammy_FL! This is incredibly helpful. Bookmarking for later. 🙏

Last edited: Mar 8, 2026 at 9:25 PM
4 7nick_SD_fit, ben_calgary, patPC_UT and 1 other
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bri_stats
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Mar 8, 2026 at 4:42 PM#24

Relevant to Semaglutide and MASH liver — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 217 → 117 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

25 5JessicaM_2024, TomFromTexas, mike.trainer_LA and 22 others
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BrianDallas92
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Mar 8, 2026 at 4:59 PM#25

Slightly tangential to Semaglutide and MASH but tammy_FL reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

43 2GraceAZ_72, carl_compliance, DanielChem_CHI and 40 others
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