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ForumsSemaglutide (Ozempic / Wegovy)Semaglutide cardiovascular benefit: SELECT trial deep dive Page 5

Semaglutide cardiovascular benefit: SELECT trial deep dive

Dr.CardioMD Thu, Mar 5, 2026 at 8:37 PM 21 replies 414 viewsPage 5 of 5
sean_dublin
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Mar 6, 2026 at 3:42 AM#21

mike_mod — that is really helpful context on Semaglutide. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Mar 6, 2026 at 4:42 AM
10 18hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 7 others
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KevinCompounds
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Mar 6, 2026 at 3:59 AM#22

To answer NicoleRaleigh's question specifically:

From a clinical standpoint, Semaglutide cardiovascular is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

26 7Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 23 others
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sarah.morrison
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Mar 6, 2026 at 4:16 AM#23

Thank you sean_dublin! This is incredibly helpful. Taking this to my next appointment. 🙏

20 14tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 17 others
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SleepDoc_PDX
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Mar 6, 2026 at 4:33 AM#24

Relevant to Semaglutide cardiovascular — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 239 → 109 mg/dL, hsCRP 6.0 → 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

36 16sophie_paris, mel_PDX, Dr.AddMedPHL and 33 others
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BiostatsBrad
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Durham, NC
Mar 6, 2026 at 4:50 AM#25

Slightly tangential to Semaglutide but sean_dublin reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

37 6NicoleRaleigh, james_edin, FranDenver and 34 others
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