Reading this thread on Long-term semaglutide (3+ hits close to home. Dad of 2 checking in — I started at 281 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 56 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Long-term semaglutid — take the leap. It was the best health decision I have ever made. ❤️

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

Relevant to Long-term semaglutide (3+ — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 213 → 113 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Thank you MariaRD! This is incredibly helpful. Taking this to my next appointment. 🙏

+1 to Dr.ObesityLA. Especially the point about "Long-term semaglutide (3+ is exactly wha..." — I have seen the same in my own experience with Long-term semaglutide (3+.