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Evidence-based GLP-1 & peptide discussion since 2023
Forumsβ€ΊSemaglutide (Ozempic / Wegovy)β€ΊA1C reduction on semaglutide: SUSTAIN program meta-analysis

A1C reduction on semaglutide: SUSTAIN program meta-analysis

A1cHero_PHX Sat, Feb 21, 2026 at 4:00 AM 22 replies 520 viewsPage 1 of 5
A1cHero_PHX
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523
2,678
Jul 2024
Phoenix, AZ
Feb 21, 2026 at 5:25 AM#1

Is anyone else STILL dealing with Wegovy shortages? I've been trying to fill my 1.7mg prescription for 2 weeks and every pharmacy within 30 miles is out. My pharmacy says "we don't have an ETA" which is incredibly frustrating.

I'm going on week 3 without my dose and I can already feel the appetite creeping back. The food noise is returning. I'm terrified of regaining the 34lbs I've lost.

What's the current situation? Is anyone finding stock? Are there any workarounds?

31 11zoe_NC, Dr.ObesityLA, NurseKim_ATL and 28 others
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mike_nyc
VIP Member
5,678
21,345
Nov 2023
New York
Online
Feb 21, 2026 at 5:42 AM#2

The shortage situation is a mess. Here's what I've gathered from the last few weeks:

  • 0.25mg and 0.5mg: Generally available β€” these are the starter doses and demand is lower because people titrate through them quickly
  • 1.0mg: Spotty β€” available at some pharmacies, not others
  • 1.7mg: Very hard to find β€” this is the dose most people settle on and the biggest bottleneck
  • 2.4mg: Also tight but slightly better availability than 1.7mg in my area

Tips that helped me find stock:

  1. Call pharmacies early in the morning on Tuesdays and Thursdays β€” that's when most receive shipments
  2. Try smaller independent pharmacies, not just the big chains
  3. Ask your pharmacy to do a "nationwide search" in their system β€” many chains can check all locations
  4. Consider a specialty pharmacy β€” they often have better access to supply
34 1stefan_berlin, Dr.EM_Chicago, pete_RVA and 31 others
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ricardo_MIA
Member
378
1,678
Sep 2024
Miami, FL
Feb 21, 2026 at 5:59 AM#3

I found stock at a Costco pharmacy last week when nowhere else had it. Worth trying if you have a membership (and you don't actually need a membership to use Costco pharmacy in most states).

37 6CanadaChris, ZaraB_AL, JakeSmashed95 and 34 others
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JessicaH_TX
Senior Member
4,123
13,456
Dec 2023
Houston, TX
Feb 21, 2026 at 6:16 AM#4

Two important things if you're going without your dose:

1. You won't lose all your progress in 2-3 weeks. Semaglutide has a half-life of ~168 hours (7 days). After missing one dose, you still have 50% of your steady-state levels. After two weeks, you're at about 25%. The drug doesn't just vanish β€” it takes several weeks to fully clear your system. So while you'll notice some return of appetite, you're not starting from zero.

2. When you get your pen, DO NOT skip ahead in dosing. If you've been off for 2+ weeks, you may want to consider restarting at your current dose rather than jumping to a higher one. If you've been off for 4+ weeks, talk to your doctor about whether to go back a dose level to avoid severe nausea.

Last edited: Feb 21, 2026 at 10:16 AM
14 22Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 11 others
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PharmHunterJen
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567
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Jul 2024
Illinois
Feb 21, 2026 at 6:33 AM#5

The FDA still has semaglutide listed on their Drug Shortage Database as of this month. Novo Nordisk has been increasing manufacturing capacity but demand continues to outpace supply globally.

From a clinical standpoint, options if you can't find your dose:

  • Dose-splitting from a higher strength: NOT recommended with Wegovy pens because the autoinjector delivers a fixed dose. But Ozempic pens can technically be dialed to custom doses. Talk to your prescriber about temporarily switching to Ozempic for more dosing flexibility.
  • Compounded semaglutide: Available from compounding pharmacies without the supply constraints of brand products. The FDA's position on this is evolving, so discuss with your provider.
  • Temporary switch to liraglutide (Saxenda): Same drug class, different molecule, much better availability. Won't be exactly the same but covers the mechanism while you wait for sema supply.

I know none of these are ideal but going without any GLP-1 therapy for an extended period increases the risk of weight regain.

17 22mike_mealprep, NicoleRaleigh, james_edin and 14 others
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