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ForumsSemaglutide (Ozempic / Wegovy)A1C reduction on semaglutide: SUSTAIN program meta-analysis Page 3

A1C reduction on semaglutide: SUSTAIN program meta-analysis

A1cHero_PHX Sat, Feb 21, 2026 at 4:00 AM 22 replies 520 viewsPage 3 of 5
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Feb 21, 2026 at 8:15 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

2 17PedsEndoPhilly, SleepDoc_PDX
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Dr.LipidDallas
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Feb 21, 2026 at 8:32 AM#12

Slightly tangential to A1C reduction on but JessicaH_TX reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 21, 2026 at 10:32 AM
48 9wei_SG, cory_ATX, lori_vegas and 45 others
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rachel_ABQ
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Feb 21, 2026 at 8:49 AM#13
DeniseRN_TPA said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. DeniseRN_TPA articulated what I have been trying to explain to my doctor for months. The A1C reduction on aspect is the most important factor.

Last edited: Feb 21, 2026 at 1:49 PM
10 9AmyNC_wife, SkepticalSean, Dr.CardioMD and 7 others
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Dr.SportsMedIN
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Feb 21, 2026 at 9:06 AM#14

Saving this for reference. Top-tier content.

30 18Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 27 others
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SleepDoc_PDX
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Feb 21, 2026 at 9:23 AM#15

Adding my data to this A1C reduction on discussion:

MetricBaselineMonth 3Month 8
Weight278 lbs223 lbs213 lbs
A1C7.2%5.8%5.4%
hsCRP7.02.01.2

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

6 19mel_PDX, Dr.AddMedPHL, newstart_MO and 3 others
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