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ForumsExercise & Body CompositionZone 2 cardio + GLP-1: synergistic metabolic benefits — evidence Page 3

Zone 2 cardio + GLP-1: synergistic metabolic benefits — evidence

MikeFit_NJ Fri, Mar 13, 2026 at 12:19 AM 18 replies 285 viewsPage 3 of 4
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Mar 13, 2026 at 4:34 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

31 7PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 28 others
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Dr.NutriCornell
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Mar 13, 2026 at 4:51 AM#12

Slightly tangential to Zone 2 cardio + GLP-1 but LabKate reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

31 19Dr.SleepRoch, laura_annarbor, JenMemphis and 28 others
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mark_tokyo
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Mar 13, 2026 at 5:08 AM#13
robert_kc said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. robert_kc articulated what I have been trying to explain to my doctor for months. The Zone 2 cardio + GLP-1 aspect is the most important factor.

Last edited: Mar 13, 2026 at 8:08 AM
21 11LibrarianMeg, bri_stats, pete_manc_UK and 18 others
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pat_auckland
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Mar 13, 2026 at 5:25 AM#14

Saving this for reference. Top-tier content.

Last edited: Mar 13, 2026 at 9:25 AM
36 8MeganSA_TX, LarryQC_SD, wanda_boise and 33 others
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HPLC_Greg
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Mar 13, 2026 at 5:42 AM#15

Adding my data to this Zone 2 cardio + GLP-1 discussion:

MetricBaselineMonth 3Month 8
Weight254 lbs224 lbs219 lbs
A1C6.8%5.8%5.4%
hsCRP8.02.01.2

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

Last edited: Mar 13, 2026 at 11:42 AM
7 16SaraMom3, Dr.MetabolicMD, RetaRick_CA and 4 others
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