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ForumsMASH / Liver DiseaseGLP-1 hepatoprotection — direct vs indirect mechanisms Page 3

GLP-1 hepatoprotection — direct vs indirect mechanisms

MASHdoc_SA Thu, Mar 12, 2026 at 4:05 PM 16 replies 402 viewsPage 3 of 4
Admin
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Mar 12, 2026 at 8:20 PM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

36 11PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 33 others
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PurityPaulOR
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Mar 12, 2026 at 8:37 PM#12

Slightly tangential to GLP-1 hepatoprotection but Dr.NateNeph reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Mar 12, 2026 at 11:37 PM
44 20MikeNYC_runner and 41 others
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Dr.Martinez
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Mar 12, 2026 at 8:54 PM#13
Dr.EndoIndy said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. Dr.EndoIndy articulated what I have been trying to explain to my doctor for months. The GLP-1 hepatoprotection aspect is the most important factor.

Last edited: Mar 13, 2026 at 1:54 AM
20 13rachel_ABQ, traveltech_sara, AttorneyGrant and 17 others
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KetoKyle
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Mar 12, 2026 at 9:11 PM#14

Saving this for reference. Top-tier content.

12 9Dr.GastroMayo, JakeBK_lifts, DerekSJ_a1c and 9 others
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labquiet_amy
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Mar 12, 2026 at 9:28 PM#15

Adding my data to this GLP-1 hepatoprotection discussion:

MetricBaselineMonth 3Month 8
Weight242 lbs242 lbs207 lbs
A1C6.6%5.8%5.4%
hsCRP6.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

7 20pete_manc_UK, anna.melb_AU, mark_tokyo and 4 others
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