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ForumsExercise & Body CompositionHIIT vs LISS cardio on GLP-1 — which preserves more muscle? Page 3

HIIT vs LISS cardio on GLP-1 — which preserves more muscle?

mike.trainer_LA Sun, Mar 8, 2026 at 3:50 AM 20 replies 410 viewsPage 3 of 4
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Mar 8, 2026 at 8:05 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Last edited: Mar 8, 2026 at 12:05 PM
45 19PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 42 others
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JessicaH_TX
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Mar 8, 2026 at 8:22 AM#12

Slightly tangential to HIIT vs LISS cardio on but TirzTom reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

21 0sarah_TO, wendy_avl, jason_paloalto and 18 others
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FranDenver
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Mar 8, 2026 at 8:39 AM#13
wanda_boise said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. wanda_boise articulated what I have been trying to explain to my doctor for months. The HIIT vs LISS cardio on aspect is the most important factor.

7 1BariatricNurseD, MASHdoc_SA, GenomicsKate and 4 others
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pete_RVA
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Mar 8, 2026 at 8:56 AM#14

Saving this for reference. Top-tier content.

Last edited: Mar 8, 2026 at 1:56 PM
31 2MikeNYC_runner and 28 others
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labquiet_amy
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Mar 8, 2026 at 9:13 AM#15

Adding my data to this HIIT vs LISS cardio on discussion:

MetricBaselineMonth 5Month 8
Weight274 lbs224 lbs209 lbs
A1C6.8%6.0%5.4%
hsCRP8.04.00.8

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

Last edited: Mar 8, 2026 at 11:13 AM
46 0pete_manc_UK, anna.melb_AU, mark_tokyo and 43 others
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