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ForumsMASH / Liver DiseaseMASH resolution without worsening fibrosis — endpoint analysis Page 3

MASH resolution without worsening fibrosis — endpoint analysis

MASHdoc_SA Thu, Mar 12, 2026 at 2:26 AM 11 replies 281 viewsPage 3 of 3
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Mar 12, 2026 at 6:41 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Last edited: Mar 12, 2026 at 10:41 AM
1 22PedsEndoPhilly
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DataDave
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Mar 12, 2026 at 6:58 AM#12

Slightly tangential to MASH resolution without but LipidDoc_ATL reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Mar 12, 2026 at 7:58 AM
17 19mike_nyc, VendorMark, COA_Karl and 14 others
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patPC_UT
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Mar 12, 2026 at 7:15 AM#13
pam_stl said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. pam_stl articulated what I have been trying to explain to my doctor for months. The MASH resolution without aspect is the most important factor.

21 7TomFromTexas, mike.trainer_LA, sarah_nash92 and 18 others
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SarahChen_PharmD
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Mar 12, 2026 at 7:32 AM#14

Saving this for reference. Top-tier content.

23 11TinaHashiRN, robert_kc, dan_philly and 20 others
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dave_SLC
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Mar 12, 2026 at 7:49 AM#15

Adding my data to this MASH resolution without discussion:

MetricBaselineMonth 5Month 8
Weight278 lbs243 lbs203 lbs
A1C7.2%6.0%5.4%
hsCRP7.04.01.2

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

17 14Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 14 others
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