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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOther Peptides & Research CompoundsIpamorelin vs Tesamorelin — anyone have experience? Page 4

Ipamorelin vs Tesamorelin — anyone have experience?

pat_auckland Fri, Nov 7, 2025 at 6:26 PM 37 replies 1,157 viewsPage 4 of 8
pat_auckland
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Jun 2024
Auckland, NZ
Nov 8, 2025 at 12:06 AM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Ipamorelin vs Tesamorelin.

To answer MikeFit_NJ: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

42 19NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 39 others
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HPLC_Greg
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Feb 2024
Research Triangle, NC
Nov 8, 2025 at 12:23 AM#17

Relevant to Ipamorelin vs Tesamorelin — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 229 → 99 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

20 4JenPlateau, SallyK_inj, CryptoCarl and 17 others
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josh_phd_bmore
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Jul 2024
Baltimore, MD
Nov 8, 2025 at 12:40 AM#18

100%. My provider said the same thing about Ipamorelin vs.

23 8zoe_NC, Dr.ObesityLA, NurseKim_ATL and 20 others
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Dr.GutHealth
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Mar 2024
Minnesota
Nov 8, 2025 at 12:57 AM#19

Slightly tangential to Ipamorelin vs Tesamorelin but DeniseRN_TPA reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

15 1Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 12 others
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PeptideChemSF
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Jan 2024
San Francisco, CA
Nov 8, 2025 at 1:14 AM#20
pat_auckland said:
Thank you all for the thoughtful replies on Ipamorelin vs Tesamorelin

This is exactly right. pat_auckland articulated what I have been trying to explain to my doctor for months. The Ipamorelin vs Tesamorelin aspect is the most important factor.

19 6BrianDallas92, labquiet_amy, emily_PDX and 16 others
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