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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSemaglutide (Ozempic / Wegovy)Why does sema make me SO tired?? Page 2

Why does sema make me SO tired??

SleepFixSam Sun, Jan 4, 2026 at 10:34 AM 14 replies 900 viewsPage 2 of 3
COA_Karl
Senior Member
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Jan 2024
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Jan 4, 2026 at 1:24 PM#6
PharmD_Rodriguez said:
— I actually dealt with this exact situation around month 3

Gonna push back on this one. Why does sema make me SO tired?? is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

3 5matt_MKE, Dr.ReproEndo, lucas_SP_BR
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Dr.PulmRoch
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Jun 2024
Rochester, MN
Jan 4, 2026 at 1:41 PM#7

Adding my data to this Why does sema make me SO discussion:

MetricBaselineMonth 3Month 8
Weight266 lbs226 lbs201 lbs
A1C7.0%5.8%5.4%
hsCRP5.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

34 18traveltech_sara, AttorneyGrant, DebRD_ATL and 31 others
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emma_london
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Oct 2024
London, UK
Jan 4, 2026 at 1:58 PM#8

roxy_nash — wow. I've been looking for this exact info for weeks.

27 16TomFromTexas, mike.trainer_LA, sarah_nash92 and 24 others
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B12Beth
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Oct 2024
Maryland
Jan 4, 2026 at 2:15 PM#9

Slightly tangential to Why does sema make me SO but carlos_SATX reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

34 21marco_milano, pam_columbus, nick_SD_fit and 31 others
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mike_mod
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Jan 4, 2026 at 2:32 PM#10

Moderator note: This thread has been getting great engagement. Please remember to cite sources when making clinical claims.

No issues to report — carry on. 👍

15 11PurityPaulOR, MaxMetOK, MounjBrad and 12 others
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