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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSemaglutide (Ozempic / Wegovy)Why does sema make me SO tired?? Page 3

Why does sema make me SO tired??

SleepFixSam Sun, Jan 4, 2026 at 10:34 AM 14 replies 900 viewsPage 3 of 3
BenResearch_OR
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Jan 4, 2026 at 2:49 PM#11
COA_Karl said:
Why does sema make me SO tired

This is exactly right. COA_Karl articulated what I have been trying to explain to my friends for months. The Why does sema make me SO aspect is what made the difference for me.

9 6julia.endo, JessicaM_2024, TomFromTexas and 6 others
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tommy_boulder
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Jan 4, 2026 at 3:06 PM#12

Reading this thread on Why does sema make me SO hits close to home. Dad of 2 checking in — I started at 281 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 56 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Why does sema make — take the leap. It was the best health decision I have ever made. ❤️

25 20TinaHashiRN, robert_kc, dan_philly and 22 others
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NicoleRaleigh
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Raleigh, NC
Jan 4, 2026 at 3:23 PM#13

roxy_nash — that is really helpful context on Why does sema make me SO. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

32 24COA_Karl, MikeFit_NJ, InsuranceTom and 29 others
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NurseAsh_DET
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Sep 2024
Detroit, MI
Jan 4, 2026 at 3:40 PM#14

To answer tommy_boulder's question specifically:

From a clinical standpoint, Why does sema make me SO is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

32 19labquiet_amy, emily_PDX, Dr.SleepRoch and 29 others
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JennaRN
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Jan 4, 2026 at 3:57 PM#15

Bookmarked 📌 The Why does sema make info in this thread is essential. Coming back to this for sure.

14 23SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 11 others
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