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ForumsMASH / Liver DiseaseFibrosis regression on GLP-1 — is scarring really reversible? Page 3

Fibrosis regression on GLP-1 — is scarring really reversible?

Dr.PathRoch Wed, Mar 4, 2026 at 3:14 PM 21 replies 557 viewsPage 3 of 5
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Mar 4, 2026 at 7:29 PM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

6 9PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 3 others
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NeuroNate
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Mar 4, 2026 at 7:46 PM#12

Slightly tangential to Fibrosis regression on but TrialNerd_Beth reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

8 4wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 5 others
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PharmHunterJen
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Mar 4, 2026 at 8:03 PM#13
tommy_boulder said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. tommy_boulder articulated what I have been trying to explain to my doctor for months. The Fibrosis regression on aspect is the most important factor.

6 0kevin_tulsa, Dr.PainCLE, mike_mealprep and 3 others
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julia.endo
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Mar 4, 2026 at 8:20 PM#14

Saving this for reference. Top-tier content.

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bri_stats
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Mar 4, 2026 at 8:37 PM#15

Adding my data to this Fibrosis regression on discussion:

MetricBaselineMonth 4Month 8
Weight266 lbs236 lbs211 lbs
A1C7.0%6.2%5.4%
hsCRP5.03.00.8

Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

42 5julia.endo, JessicaM_2024, TomFromTexas and 39 others
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