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ForumsMASH / Liver DiseaseFibrosis regression on GLP-1 — is scarring really reversible? Page 4

Fibrosis regression on GLP-1 — is scarring really reversible?

Dr.PathRoch Wed, Mar 4, 2026 at 3:14 PM 21 replies 557 viewsPage 4 of 5
matt_MKE
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Milwaukee, WI
Mar 4, 2026 at 8:54 PM#16

Just wanted to say — for anyone reading this Fibrosis regression thread who is feeling discouraged: it gets better. The first 6 weeks are the hardest. Hang in there. 💪

42 10andrew_nyc, Dr.EndoEP, GraceAZ_72 and 39 others
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traveltech_sara
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Jan 2025
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Mar 4, 2026 at 9:11 PM#17

As a healthcare provider, I want to add some clinical context to this discussion on Fibrosis regression on GLP-1 is.

Building on what julia.endo said — the evidence base here is well-established. The key publications to reference are from the SELECT program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
23 6LarryQC_SD, wanda_boise, NurseAsh_DET and 20 others
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Dr.NutriCornell
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Ithaca, NY
Mar 4, 2026 at 9:28 PM#18
matt_MKE said:
The first 6 weeks are the hardest

Gonna push back on this one. Fibrosis regression on GLP-1 is is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

50 4laura_annarbor, JenMemphis, pat_auckland and 47 others
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kate.chem
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Mar 4, 2026 at 9:45 PM#19

Subscribing to this thread. Fibrosis regression on is exactly what I've been researching. 🙏

Last edited: Mar 5, 2026 at 12:45 AM
46 19jennifer_SEA, tyler_CSCS, VanRx_Mike and 43 others
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SleepFixSam
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Nov 2024
Hawaii
Mar 4, 2026 at 10:02 PM#20

Reading this thread on Fibrosis regression on hits close to home. Dad of 2 checking in — I started at 281 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 56 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Fibrosis regression — take the leap. It was the best health decision I have ever made. ❤️

24 10fiona_VT, denise_HTX, raj_cambridge and 21 others
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