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ForumsMASH / Liver DiseaseMy liver enzyme journey — ALT from 98 to 19 on semaglutide Page 3

My liver enzyme journey — ALT from 98 to 19 on semaglutide

DerekSJ_a1c Sun, Mar 1, 2026 at 9:10 AM 29 replies 552 viewsPage 3 of 6
BiostatsBrad
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Mar 1, 2026 at 1:25 PM#11

+1 to Dr.ObesityMed. Especially the point about "Re: My liver enzyme journey ALT — the s..." — I have seen the same in my own experience with My liver enzyme journey .

Last edited: Mar 1, 2026 at 2:25 PM
49 22LindaRN_retired, tommy_boulder, hyun_seoul and 46 others
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wanda_boise
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Aug 2024
Boise, ID
Mar 1, 2026 at 1:42 PM#12

Want to share my personal experience related to My liver enzyme journey ALT since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 261 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 18 months later: I am down 46 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The My liver enzyme aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

21 15marco_milano, pam_columbus, nick_SD_fit and 18 others
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carlos_SATX
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Oct 2024
San Antonio, TX
Mar 1, 2026 at 1:59 PM#13

Dr.SurgeonPGH — that is really helpful context on My liver enzyme journey . Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

8 16Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 5 others
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anna.melb_AU
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Apr 2024
Melbourne, AU
Mar 1, 2026 at 2:16 PM#14

To answer wanda_boise's question specifically:

From a clinical standpoint, My liver enzyme journey ALT is well-supported by the literature.

The short answer: follow the standard titration protocol and reassess at 4-6 weeks.

The longer answer involves pharmacokinetic considerations around steady-state concentrations, which I am happy to elaborate on if helpful.

43 20tammy_FL, Dr.LipidDallas, alex_tucson and 40 others
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Dr.DermMIA
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Miami, FL
Mar 1, 2026 at 2:33 PM#15

Saving this for reference. Top-tier content.

8 16SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 5 others
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