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ForumsMASH / Liver DiseaseMy liver enzyme journey — ALT from 98 to 19 on semaglutide Page 5

My liver enzyme journey — ALT from 98 to 19 on semaglutide

DerekSJ_a1c Sun, Mar 1, 2026 at 9:10 AM 29 replies 552 viewsPage 5 of 6
Dr.EM_Chicago
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567
2,567
May 2024
Chicago, IL
Mar 1, 2026 at 4:15 PM#21

Just wanted to say — for anyone reading this My liver enzyme thread who is feeling discouraged: it gets better. The first few weeks are the hardest. Hang in there. 💪

33 6jim_asheville, matt_MKE, Dr.ReproEndo and 30 others
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ingrid_STO
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345
1,456
Jul 2024
Stockholm, SE
Mar 1, 2026 at 4:32 PM#22

Want to share my personal experience related to My liver enzyme journey ALT since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 256 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 81 lbs, my labs have normalized, and I am off 2 of my 3 medications. The My liver enzyme aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

50 13COA_Karl, MikeFit_NJ, InsuranceTom and 47 others
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EndoResFellow
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456
2,345
Sep 2024
Baltimore, MD
Mar 1, 2026 at 4:49 PM#23

Clinical perspective on My liver enzyme journey ALT from 98 to:

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

Last edited: Mar 1, 2026 at 6:49 PM
35 3paul_denver, TinaHashiRN, robert_kc and 32 others
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SleepFixSam
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212
678
Nov 2024
Hawaii
Mar 1, 2026 at 5:06 PM#24

Thank you ingrid_STO! This is incredibly helpful. Taking this to my next appointment. 🙏

5 18denise_HTX, raj_cambridge, ingrid_STO and 2 others
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labquiet_amy
Senior Member
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6,789
Mar 2024
Cambridge, MA
Mar 1, 2026 at 5:23 PM#25

Relevant to My liver enzyme journey ALT — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 219 → 119 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

46 10pete_manc_UK, anna.melb_AU, mark_tokyo and 43 others
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