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ForumsMASH / Liver DiseaseMy liver enzyme journey — ALT from 98 to 19 on semaglutide Page 6

My liver enzyme journey — ALT from 98 to 19 on semaglutide

DerekSJ_a1c Sun, Mar 1, 2026 at 9:10 AM 29 replies 552 viewsPage 6 of 6
BenResearch_OR
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Mar 1, 2026 at 5:40 PM#26

Same experience here with My liver enzyme journey . Dr.EM_Chicago described it perfectly.

8 14julia.endo, JessicaM_2024, TomFromTexas and 5 others
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Dr.ObesityMed
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Mar 1, 2026 at 5:57 PM#27
ingrid_STO said:
I started my GLP-1 journey in October 2024 at 256 lbs with prediabetes and hypertension

Gonna push back on this one. My liver enzyme journey ALT from is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

35 20PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 32 others
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fiona_glasgow
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Glasgow, UK
Mar 1, 2026 at 6:14 PM#28

Want to share my personal experience related to My liver enzyme journey ALT since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 262 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 10 months later: I am down 47 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The My liver enzyme aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

5 6KevinCompounds, TirzTom, TrialTracker_MD and 2 others
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carlos_SATX
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San Antonio, TX
Mar 1, 2026 at 6:31 PM#29

Saving this for reference. Quality thread.

20 22LindaRN_retired, tommy_boulder, hyun_seoul and 17 others
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zoe_NC
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Nov 2024
Charlotte, NC
Mar 1, 2026 at 6:48 PM#30

BenResearch_OR — that is really helpful context on My liver enzyme journey . Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

17 24mike_mealprep, NicoleRaleigh, james_edin and 14 others
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