Slightly tangential to STEP 1-5 trials but rick_sfbay reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on STEP 1-5 trials.
To answer kevin_tulsa: I started tracking everything in a spreadsheet from day 1.
Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.
Verify Your PeptidesAdding my data to this STEP 1-5 trials discussion:
| Metric | Baseline | Month 3 | Month 8 |
|---|---|---|---|
| Weight | 250 lbs | 215 lbs | 195 lbs |
| A1C | 6.4% | 5.8% | 5.4% |
| hsCRP | 4.0 | 2.0 | 0.8 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.
Reading this thread on STEP 1-5 trials hits close to home. Dad of 2 checking in — I started at 261 lbs and felt like I would tried everything.
7 months on tirz and I am a different person. Not just the 36 lbs lost — my energy, my mood, my relationship with food. All transformed.
If you are on the fence about STEP 1-5 trials — take the leap. It was the best health decision I have ever made. ❤️