Congrats anders_CPH!! Keep going — you're doing incredible. 🎉

Reading this thread on 0.25mg → 2.4mg titration hits close to home. Night shift nurse — I started at 291 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 66 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about 0.25mg → 2.4mg — take the leap. It was the best health decision I have ever made. ❤️

As a pharmacist, I want to add some clinical context to this discussion on 0.25mg → 2.4mg titration optimal.

Building on what hans_munich said — the evidence base here is robust. The key publications to reference are from the SUSTAIN program[1].

Key clinical points:

1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
2. Side effect profile is predictable and usually manageable with standard protocols
3. Monitoring should include baseline labs and follow-up at 3-month intervals
4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

Dr.GastroMayo — wow. I've been looking for this exact info for weeks.

Adding my data to this 0.25mg → 2.4mg titration discussion:

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.