🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionCreatine kinase elevations on GLP-1 — what worked for you? Page 2

Creatine kinase elevations on GLP-1 — what worked for you?

A1cHero_PHX Mon, Jan 5, 2026 at 5:38 AM 37 replies 1,327 viewsPage 2 of 8
Dr.ObesityLA
VIP Member
3,567
19,876
Dec 2023
Los Angeles, CA
Jan 5, 2026 at 8:28 AM#6

Okay the water retention thing is what scares me. I weigh myself daily (I know, I know) and seeing the scale go UP would honestly send me into a spiral. My brain knows it's water but my anxiety doesn't care.

Anyone have tips for mentally handling that initial scale bump? Or should I just not weigh myself for 2 weeks when I start?

17 4zoe_NC, Dr.ObesityLA, NurseKim_ATL and 14 others
Reply Quote Save Share Report
Dr.KarenChen
VIP Member
4,210
24,567
Nov 2023
San Francisco, CA
Jan 5, 2026 at 8:45 AM#7

Honestly? Don't weigh yourself for 3 weeks when you start creatine. Or switch to weekly weigh-ins using a rolling average. The day-to-day fluctuations on creatine + GLP-1 + normal water/food variation can be like 2-3kg in either direction on any given day. It'll drive you nuts.

Better metrics while on creatine: waist circumference, how clothes fit, progress photos, lifting numbers. The scale becomes a less useful tool (it was never a great one honestly).

27 17JessicaM_2024, TomFromTexas, mike.trainer_LA and 24 others
Reply Quote Save Share Report
mike_mod
Moderator
7,234
19,823
Nov 2023
New York
Online
Jan 5, 2026 at 9:02 AM#8

I'll play devil's advocate slightly. While creatine is safe and well-studied, I think the GLP-1 community sometimes treats it as a magic bullet for muscle preservation. It helps, yes, but the effect size is modest. The hierarchy should be:

  1. Adequate protein intake (1.2-1.6g/kg) — biggest impact
  2. Consistent resistance training with progressive overload — second biggest
  3. Adequate sleep (7-9 hrs) — often overlooked, hugely important
  4. Creatine 5g/day — helpful but marginal compared to the above

Don't add creatine while eating 60g protein and doing no exercise. Fix the foundations first.

13 22DoseLogDan, SleepFixSam, PurityPaulOR and 10 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides
bbq_ray_KC
Member
378
1,678
Jul 2024
Kansas City, KS
Jan 5, 2026 at 9:19 AM#9

Totally fair hierarchy. Creatine is the cherry on top, not the cake itself. Thanks everyone for the thorough discussion — this is exactly the kind of evidence-based conversation I was hoping for. Starting 5g/day tomorrow, no loading phase, with breakfast. Will report back in a month. 💊🏋️

Last edited: Jan 5, 2026 at 11:19 AM
24 3WendyG_ATL, SaraMom3, Dr.MetabolicMD and 21 others
Reply Quote Save Share Report

Similar Threads

Resistance training prevents 73% lean mass loss on semaglutide — RCT review11 replies
DEXA scan longitudinal data — 12 months on GLP-1 + lifting18 replies
Zone 2 cardio + GLP-1: synergistic metabolic benefits — evidence18 replies
Creatine kinase elevations on GLP-1 — exercise-induced or concerning?14 replies
Body recomposition protocol: GLP-1 + progressive overload + high protein8 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register