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ForumsExercise & Body CompositionCreatine kinase elevations on GLP-1 — what worked for you? Page 5

Creatine kinase elevations on GLP-1 — what worked for you?

A1cHero_PHX Mon, Jan 5, 2026 at 5:38 AM 37 replies 1,327 viewsPage 5 of 8
james_edin
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Jan 5, 2026 at 12:43 PM#21

Want to share my personal experience related to Creatine kinase elevations on since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 278 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 18 months later: I am down 53 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Creatine kinase aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

17 11mona_PHX, andrew_nyc, Dr.EndoEP and 14 others
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mike_mod
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Jan 5, 2026 at 1:00 PM#22

Moderator note: This thread has been getting great engagement. Please remember to cite sources when making clinical claims.

No issues to report — carry on. 👍

Last edited: Jan 5, 2026 at 3:00 PM
1 17TomTeleRx
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labquiet_amy
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Jan 5, 2026 at 1:17 PM#23

Adding my data to this Creatine kinase discussion:

MetricBaselineMonth 5Month 8
Weight250 lbs240 lbs215 lbs
A1C6.4%6.0%5.4%
hsCRP4.04.00.8

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

Last edited: Jan 5, 2026 at 3:17 PM
23 19LibrarianMeg, bri_stats, pete_manc_UK and 20 others
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TirzTom
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Jan 5, 2026 at 1:34 PM#24

NauseaFreeNow — wow. I've been looking for this exact info for weeks.

Last edited: Jan 5, 2026 at 5:34 PM
12 15SandraNC_45, Dr.EndoIndy, tom_AK and 9 others
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PharmHunterJen
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Jul 2024
Illinois
Jan 5, 2026 at 1:51 PM#25
wanda_boise said:
Creatine kinase is exactly what I've been researching

This is exactly right. wanda_boise articulated what I have been trying to explain to my doctor for months. The Creatine kinase aspect is the most important factor.

36 12mike_mealprep, NicoleRaleigh, james_edin and 33 others
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