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ForumsMASH / Liver DiseaseMASH resolution without worsening fibrosis — 6 month update Page 3

MASH resolution without worsening fibrosis — 6 month update

patPC_UT Fri, Jan 23, 2026 at 4:13 PM 11 replies 565 viewsPage 3 of 3
nick_SD_fit
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Jan 23, 2026 at 8:28 PM#11
TrialNerd_Beth said:
MASH resolution without worsening is not that straightforward in my experience

This is exactly right. TrialNerd_Beth articulated what I have been trying to explain to my friends for months. The MASH resolution without aspect is what made the difference for me.

Last edited: Jan 23, 2026 at 10:28 PM
37 14SkepticalSean, Dr.CardioMD, EndoResFellow and 34 others
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Admin
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Jan 23, 2026 at 8:45 PM#12

Reading this thread on MASH resolution without hits close to home. Dad of 2 checking in — I started at 265 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 40 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about MASH resolution — take the leap. It was the best health decision I have ever made. ❤️

11 8SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 8 others
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RunnerRach
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Jan 23, 2026 at 9:02 PM#13

PeptideChemSF — that is really helpful context on MASH resolution without. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Jan 24, 2026 at 12:02 AM
16 12Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 13 others
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pete_nash
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Nashville, TN
Jan 23, 2026 at 9:19 PM#14

To answer Admin's question specifically:

From a clinical standpoint, MASH resolution without is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

6 23SarahChen_PharmD, sarah.morrison, NeuroNate and 3 others
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robert_kc
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Kansas City, MO
Jan 23, 2026 at 9:36 PM#15

Bookmarked 📌 The MASH resolution info in this thread is essential. Coming back to this for sure.

22 8PharmHunterJen, TomTeleRx, DoseLogDan and 19 others
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