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ForumsOther Peptides & Research CompoundsSS-31 (Elamipretide) — need advice

SS-31 (Elamipretide) — need advice

anna.melb_AU Fri, Apr 25, 2025 at 12:01 AM 10 replies 1,300 viewsPage 1 of 2
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anna.melb_AU
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Apr 2024
Melbourne, AU
Apr 25, 2025 at 1:26 AM#1

My endo and I disagree about ss-31 (elamipretide) need advice and I want a reality check.

They are saying that I do not need to worry about it but everything I have read here suggests otherwise.

I trust this community's collective knowledge but I also do not want to go against medical advice without good reason. What would you do?

26 23DerekSJ_a1c, paige_pharma, emma_london and 23 others
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Dr.BariatricHTX
Senior Member
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Feb 2024
Houston, TX
Apr 25, 2025 at 1:43 AM#2

SS-31 (Elamipretide) need advice — I actually dealt with this exact situation a few weeks ago.

Short answer: it depends on your starting point. Longer answer: I wrote about my experience in the dosing forum if you want the full details.

42 20pete_RVA, CarlaRPh_TPA, steph_laguna and 39 others
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mel_PDX
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Dec 2024
Portland, OR
Apr 25, 2025 at 2:00 AM#3
Dr.BariatricHTX said:
Short answer: it depends on your starting point

Completely agree with Dr.BariatricHTX. I would add that SS-31 (Elamipretide) need also has implications for long-term metabolic health that sometimes get overlooked in these discussions.

In my case, following a similar approach led to significant improvements compared to what I was doing before.

27 21PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 24 others
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PeptideSynthNJ
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Aug 2024
Princeton, NJ
Apr 25, 2025 at 2:17 AM#4

+1. This mirrors my journey exactly. The SS-31 (Elamipretide) discussion here is so valuable.

22 8MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 19 others
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LipidDoc_ATL
Senior Member
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Apr 2024
Atlanta, GA
Apr 25, 2025 at 2:34 AM#5

As a pharmacist, I want to add some clinical context to this discussion on SS-31 (Elamipretide) need advice.

Building on what anna.melb_AU said — the evidence base here is robust. The key publications to reference are from the SUSTAIN program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
45 16KristenIndy, MarkLI_maint, Dr.PeteFamMed and 42 others
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