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ForumsSide Effects & ManagementInjection site reactions — prevention and management guide Page 2

Injection site reactions — prevention and management guide

JennaRN Tue, Mar 10, 2026 at 7:53 PM 8 replies 172 viewsPage 2 of 2
ben_calgary
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Oct 2024
Calgary, CA
Mar 10, 2026 at 10:43 PM#6

UPDATE — tried warming + icing:

Took the pen out 30 min early, iced the spot for 3 min before, injected slowly (held 10 seconds), iced for 5 min after, didn't rub.

Result: still got a small lump but it's maybe 60% smaller than usual and the redness cleared by day 2 instead of day 5. HUGE improvement!! Going to keep doing this. Thank you all so much 🙏

Last edited: Mar 11, 2026 at 4:43 AM
42 2KetoKyle, CanadaChris, ZaraB_AL and 39 others
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claudia_zurich
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Jul 2024
Zurich, CH
Mar 10, 2026 at 11:00 PM#7

Glad that helped! The warming is probably the single biggest factor. That medication is viscous when cold and creates more tissue disruption on injection. Most patients who implement the warming step alone see significant improvement.

29 17tammy_FL, Dr.LipidDallas, alex_tucson and 26 others
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RegAffairsDC
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May 2024
Washington, DC
Mar 10, 2026 at 11:17 PM#8

Great improvement Laura! If the smaller lumps still bother you, a thin layer of OTC hydrocortisone cream on the injection site after the post-injection icing can help with the residual inflammation. Just don't apply it BEFORE injection — you want the area clean and dry pre-injection. 👩‍⚕️

36 21hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 33 others
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