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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseHas anyone dealt with semaglutide liver fat quantification? Page 3

Has anyone dealt with semaglutide liver fat quantification?

NeuroNate Sun, Jan 4, 2026 at 3:45 PM 24 replies 886 viewsPage 3 of 5
Admin
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Jan 4, 2026 at 8:00 PM#11

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

Last edited: Jan 5, 2026 at 12:00 AM
36 5PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 33 others
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Dr.GutHealth
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Jan 4, 2026 at 8:17 PM#12

Clinical perspective on Has anyone dealt with semaglutide liver:

I have managed roughly 300 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

8 1tyler_CSCS, VanRx_Mike, steve_okc and 5 others
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Dr.ReproEndo
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Jan 4, 2026 at 8:34 PM#13
Admin said:
Just a reminder to keep things civil and evidence-based

I respect Admin perspective but I think this oversimplifies things a bit. Re: Has anyone dealt with — the effect size varies considerably by population.

I am not saying Admin wrong entirely — just that the picture is more nuanced than a blanket statement. The STEP data specifically shows dose-dependent variation.

Last edited: Jan 4, 2026 at 9:34 PM
43 13Dr.EndoEP, GraceAZ_72, carl_compliance and 40 others
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KarenAZ_mom
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Jan 4, 2026 at 8:51 PM#14

Reading this thread on Has anyone dealt with hits close to home. Dad of 2 checking in — I started at 297 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 72 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Has anyone dealt — take the leap. It was the best health decision I have ever made. ❤️

36 23LibrarianMeg, bri_stats, pete_manc_UK and 33 others
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emma_london
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Jan 4, 2026 at 9:08 PM#15

Bookmarked 📌 The Has anyone dealt info in this thread is essential. Coming back to this for sure.

29 22julia.endo, JessicaM_2024, TomFromTexas and 26 others
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