🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementGLP-1 and gastroparesis — when delayed emptying becomes pathological Page 2

GLP-1 and gastroparesis — when delayed emptying becomes pathological

Dr.GutHealth Tue, Mar 10, 2026 at 12:16 AM 8 replies 324 viewsPage 2 of 2
Dr.NutriCornell
Senior Member
1,345
6,234
Mar 2024
Ithaca, NY
Mar 10, 2026 at 3:06 AM#6

Glad you're improving. For the community — this situation highlights why surgical patients should be particularly careful. The AGA and ASA have issued guidance that GLP-1 RAs should be held for at least 1 week (semaglutide) to 3 weeks before elective procedures requiring anesthesia, because residual gastroparesis increases aspiration risk during intubation.

If you're on a GLP-1 RA and have an upcoming surgery, tell your anesthesiologist even if your surgeon didn't ask. This is an active patient safety concern.

Last edited: Mar 10, 2026 at 5:06 AM
37 2emily_PDX, Dr.SleepRoch, laura_annarbor and 34 others
Reply Quote Save Share Report
rachel_ABQ
Member
178
890
Dec 2024
Albuquerque, NM
Mar 10, 2026 at 3:23 AM#7

This is exactly why I get nervous about these drugs being treated so casually. They're powerful medications that fundamentally alter GI physiology. The vast majority do fine, but the people who don't can end up in serious situations. Informed consent and regular follow-up with a knowledgeable provider are non-negotiable.

43 24DadBodDave, AmyNC_wife, SkepticalSean and 40 others
Reply Quote Save Share Report
PeptideChemSF
Senior Member
1,890
9,012
Jan 2024
San Francisco, CA
Mar 10, 2026 at 3:40 AM#8

FINAL UPDATE — 8 weeks post-discontinuation: Repeat gastric emptying study is normal. 8% retention at 4 hours (down from 62%). I'm eating normally again, no nausea, no vomiting. Full reversal.

My endocrinologist and GI doc are discussing whether I could trial a lower dose or a different GLP-1 RA in the future with close monitoring. For now, I'm just grateful my gut is working again. Thank you to everyone who shared their experience — it helped me stay calm during a really scary time.

44 7FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 41 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results

Similar Threads

Nausea incidence by dose tier — STEP and SURMOUNT meta-analysis16 replies
Constipation on GLP-1: pathophysiology and fiber protocol5 replies
Alopecia on GLP-1 — telogen effluvium differential diagnosis3 replies
Gallbladder disease risk — cholelithiasis data from clinical trials12 replies
Pancreatitis risk assessment — pooled safety analysis15 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register