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ForumsSide Effects & ManagementAcid reflux/GERD worsening on GLP-1 — PPI interaction data Page 2

Acid reflux/GERD worsening on GLP-1 — PPI interaction data

Dr.GastroMayo Sun, Mar 1, 2026 at 7:16 PM 20 replies 733 viewsPage 2 of 4
sarah_nash92
Member
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Jun 2024
Nashville, TN
Mar 1, 2026 at 10:06 PM#6

100%. My provider said the same thing about Acid reflux/GERD.

Last edited: Mar 2, 2026 at 4:06 AM
23 4NauseaFreeNow, SteveThurs, B12Beth and 20 others
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Dr.GastroMayo
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Jan 2024
Mayo Clinic, MN
Mar 1, 2026 at 10:23 PM#7

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Acid reflux/GERD.

To answer labquiet_amy: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

32 18VendorMark, COA_Karl, MikeFit_NJ and 29 others
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HPLC_Greg
Senior Member
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8,901
Feb 2024
Research Triangle, NC
Mar 1, 2026 at 10:40 PM#8

Adding my data to this Acid reflux/GERD discussion:

MetricBaselineMonth 3Month 6
Weight240 lbs240 lbs195 lbs
A1C6.4%5.8%5.2%
hsCRP4.02.00.6

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

Last edited: Mar 2, 2026 at 4:40 AM
37 13RetaRick_CA, JenPlateau, SallyK_inj and 34 others
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mia_MS2
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23
Mar 2026
Ann Arbor, MI
Mar 1, 2026 at 10:57 PM#9

+1 to Dr.GastroMayo. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Acid reflux/GERD.

43 11steve_okc, dave_SLC, FDA_TrackerJim and 40 others
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steph_laguna
Member
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Nov 2024
Laguna Beach, CA
Mar 1, 2026 at 11:14 PM#10

Slightly tangential to Acid reflux/GERD but rachel_ABQ reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Mar 2, 2026 at 5:14 AM
14 18marco_milano, pam_columbus, nick_SD_fit and 11 others
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