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Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionCreatine loading vs maintenance on GLP-1 — need advice Page 2

Creatine loading vs maintenance on GLP-1 — need advice

DebRD_ATL Sun, Nov 2, 2025 at 5:27 AM 10 replies 986 viewsPage 2 of 2
traveltech_sara
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Nov 2, 2025 at 8:17 AM#6

Okay the water retention thing is what scares me. I weigh myself daily (I know, I know) and seeing the scale go UP would honestly send me into a spiral. My brain knows it's water but my anxiety doesn't care.

Anyone have tips for mentally handling that initial scale bump? Or should I just not weigh myself for 2 weeks when I start?

10 9MeganSA_TX, LarryQC_SD, wanda_boise and 7 others
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josh_phd_bmore
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Jul 2024
Baltimore, MD
Nov 2, 2025 at 8:34 AM#7

Honestly? Don't weigh yourself for 3 weeks when you start creatine. Or switch to weekly weigh-ins using a rolling average. The day-to-day fluctuations on creatine + GLP-1 + normal water/food variation can be like 2-3kg in either direction on any given day. It'll drive you nuts.

Better metrics while on creatine: waist circumference, how clothes fit, progress photos, lifting numbers. The scale becomes a less useful tool (it was never a great one honestly).

Last edited: Nov 2, 2025 at 10:34 AM
14 3Dr.ObesityLA, NurseKim_ATL, paul_denver and 11 others
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JennaRN
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Colorado
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Nov 2, 2025 at 8:51 AM#8

I'll play devil's advocate slightly. While creatine is safe and well-studied, I think the GLP-1 community sometimes treats it as a magic bullet for muscle preservation. It helps, yes, but the effect size is modest. The hierarchy should be:

  1. Adequate protein intake (1.2-1.6g/kg) — biggest impact
  2. Consistent resistance training with progressive overload — second biggest
  3. Adequate sleep (7-9 hrs) — often overlooked, hugely important
  4. Creatine 5g/day — helpful but marginal compared to the above

Don't add creatine while eating 60g protein and doing no exercise. Fix the foundations first.

Last edited: Nov 2, 2025 at 9:51 AM
50 22BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 47 others
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SkepticalSean
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Jan 2025
Maine
Nov 2, 2025 at 9:08 AM#9

Totally fair hierarchy. Creatine is the cherry on top, not the cake itself. Thanks everyone for the thorough discussion — this is exactly the kind of evidence-based conversation I was hoping for. Starting 5g/day tomorrow, no loading phase, with breakfast. Will report back in a month. 💊🏋️

2 9tammy_FL, Dr.LipidDallas
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