🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementDiarrhea vs constipation on GLP-1 — why different people get different GI effects Page 2

Diarrhea vs constipation on GLP-1 — why different people get different GI effects

Dr.GutHealth Fri, Feb 27, 2026 at 11:45 PM 15 replies 580 viewsPage 2 of 3
Dr.NephBHM_UK
Member
456
2,123
Jun 2024
Birmingham, UK
Feb 28, 2026 at 2:35 AM#6

Glad it resolved. A few additional points for everyone reading this later:

When constipation on GLP-1s requires medical attention:

  • No BM for 7+ days despite OTC interventions
  • Severe abdominal pain or distension
  • Vomiting (could indicate obstruction)
  • Blood in stool or rectal bleeding
  • Fecal impaction symptoms (constant urge, inability to pass, leaking of liquid stool around impaction)

Also — and I say this gently — make sure you're actually eating enough. Some patients get so focused on appetite suppression that they're consuming <800 calories and barely any fiber. Your colon needs bulk to work with. Even on a GLP-1, aim for 20-25g of fiber daily.

Last edited: Feb 28, 2026 at 8:35 AM
45 16Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 42 others
Reply Quote Save Share Report
Dr.RenalNash
VIP Member
1,234
7,890
Mar 2024
Nashville, TN
Feb 28, 2026 at 2:52 AM#7

Adding my two cents: a squatty potty (or any footstool that gets your knees above your hips) made a real difference for me. Changes the angle of the anorectal junction. Combined with Miralax it went from "impossible" to "manageable."

Also seconding the walking recommendation. On days I walk 30+ minutes, things move. On days I sit at my desk all day, nothing.

14 13pam_stl, wei_SG, cory_ATX and 11 others
Reply Quote Save Share Report
DataDave
Senior Member
1,678
8,901
Apr 2024
Washington
Online
Feb 28, 2026 at 3:09 AM#8

One more underrated tip: warm beverages. Hot coffee in the morning has a well-documented prokinetic effect on the colon. Even if the drug is slowing your GI tract, caffeine and the gastrocolic reflex from warm liquid can help kickstart things. I have a cup of hot coffee within 20 minutes of waking up and it's the most reliable part of my constipation management.

Last edited: Feb 28, 2026 at 4:09 AM
23 17LondonLisa, mike_nyc, VendorMark and 20 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results

Similar Threads

Nausea incidence by dose tier — STEP and SURMOUNT meta-analysis16 replies
Constipation on GLP-1: pathophysiology and fiber protocol5 replies
Alopecia on GLP-1 — telogen effluvium differential diagnosis3 replies
Gallbladder disease risk — cholelithiasis data from clinical trials12 replies
Pancreatitis risk assessment — pooled safety analysis15 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register