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ForumsSide Effects & ManagementDiarrhea vs constipation on GLP-1 — why different people get different GI effects Page 3

Diarrhea vs constipation on GLP-1 — why different people get different GI effects

Dr.GutHealth Fri, Feb 27, 2026 at 11:45 PM 15 replies 580 viewsPage 3 of 3
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Feb 28, 2026 at 4:00 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

44 11PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 41 others
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Dr.LipidDallas
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Feb 28, 2026 at 4:17 AM#12

Slightly tangential to Diarrhea vs constipation but DanielChem_CHI reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 28, 2026 at 6:17 AM
43 12wei_SG, cory_ATX, lori_vegas and 40 others
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JessicaH_TX
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Feb 28, 2026 at 4:34 AM#13
matt_MKE said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. matt_MKE articulated what I have been trying to explain to my doctor for months. The Diarrhea vs constipation aspect is the most important factor.

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SteveThurs
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Feb 28, 2026 at 4:51 AM#14

Saving this for reference. Top-tier content.

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Dr.PathRoch
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Feb 28, 2026 at 5:08 AM#15

Adding my data to this Diarrhea vs constipation discussion:

MetricBaselineMonth 3Month 8
Weight242 lbs227 lbs207 lbs
A1C6.6%5.8%5.4%
hsCRP6.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

Last edited: Feb 28, 2026 at 11:08 AM
6 7Dr.MetabolicMD, RetaRick_CA, JenPlateau and 3 others
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