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ForumsSide Effects & ManagementMood changes on GLP-1 — depression, anxiety, or medication effect? Page 4

Mood changes on GLP-1 — depression, anxiety, or medication effect?

Dr.AddMedPHL Sat, Feb 21, 2026 at 7:17 PM 19 replies 547 viewsPage 4 of 4
SaraMom3
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2,345
Aug 2024
Ohio
Feb 22, 2026 at 12:57 AM#16

Congrats JennaRN!! Keep going — you're doing incredible. 🎉

Last edited: Feb 22, 2026 at 4:57 AM
34 13BethLabQueen, ChrisMacros, KetoKyle and 31 others
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PeptideChemSF
Senior Member
1,890
9,012
Jan 2024
San Francisco, CA
Feb 22, 2026 at 1:14 AM#17

Reading this thread on Mood changes on GLP-1 hits close to home. Night shift nurse — I started at 271 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 46 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Mood changes on — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Feb 22, 2026 at 5:14 AM
49 18dave_SLC, FDA_TrackerJim, ricardo_MIA and 46 others
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josh_phd_bmore
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389
1,678
Jul 2024
Baltimore, MD
Feb 22, 2026 at 1:31 AM#18

Adding my data to this Mood changes on GLP-1 discussion:

MetricBaselineMonth 3Month 8
Weight242 lbs232 lbs207 lbs
A1C6.6%5.8%5.4%
hsCRP6.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

17 1zoe_NC, Dr.ObesityLA, NurseKim_ATL and 14 others
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JenMemphis
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267
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Jan 2025
Memphis, TN
Feb 22, 2026 at 1:48 AM#19

Reading this thread on Mood changes on GLP-1 hits close to home. Dad of 2 checking in — I started at 293 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 68 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Mood changes on — take the leap. It was the best health decision I have ever made. ❤️

36 18wanda_boise, NurseAsh_DET, BenResearch_OR and 33 others
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amy_econ_NJ
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May 2024
Princeton, NJ
Feb 22, 2026 at 2:05 AM#20

JenMemphis — that is really helpful context on Mood changes on GLP-1 . Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

27 23NurseLeah_Nash, gary_naperville, sean_dublin and 24 others
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