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ForumsSide Effects & ManagementGLP-1 and menstrual irregularity — hormone changes during weight loss Page 3

GLP-1 and menstrual irregularity — hormone changes during weight loss

Dr.ReproEndo Wed, Feb 11, 2026 at 7:32 PM 15 replies 681 viewsPage 3 of 3
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Feb 11, 2026 at 11:47 PM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Last edited: Feb 12, 2026 at 3:47 AM
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Dr.LipidDallas
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Feb 12, 2026 at 12:04 AM#12

Slightly tangential to GLP-1 and menstrual but JessicaH_TX reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

3 7wei_SG, cory_ATX, lori_vegas
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Dr.CardioMD
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Feb 12, 2026 at 12:21 AM#13
mike_mealprep said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. mike_mealprep articulated what I have been trying to explain to my doctor for months. The GLP-1 and menstrual aspect is the most important factor.

3 6tony_orlando, Dr.NephBHM_UK, kim_atl_prep
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anna.melb_AU
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Feb 12, 2026 at 12:38 AM#14

Saving this for reference. Top-tier content.

Last edited: Feb 12, 2026 at 4:38 AM
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lucas_SP_BR
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Feb 12, 2026 at 12:55 AM#15

Adding my data to this GLP-1 and menstrual discussion:

MetricBaselineMonth 5Month 8
Weight262 lbs227 lbs197 lbs
A1C6.6%6.0%5.4%
hsCRP6.04.01.2

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

Last edited: Feb 12, 2026 at 2:55 AM
5 1tampaLisa73, KarenAZ_mom, zoe_NC and 2 others
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