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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsMarathon PR after 80 lbs weight loss — race day report

Marathon PR after 80 lbs weight loss — race day report

MikeNYC_runner Fri, Feb 27, 2026 at 3:02 PM 25 replies 875 viewsPage 1 of 5
MikeNYC_runner
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Feb 27, 2026 at 4:27 PM#1

🎉 MILESTONE: Marathon PR after 80 lbs weight!

I can not believe I am typing this. A year ago I was in a very different place.

Numbers: A1C was 7.5, now 5.0.

Thank you to this community for keeping me sane through the hard parts. You know who you are. 🙏

2 24PedsEndoPhilly, SleepDoc_PDX
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PeptideChemSF
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Feb 27, 2026 at 4:44 PM#2

To answer the question about Marathon PR after 80 lbs weight loss race day report — in my experience this comes down to a few key factors.

I have been dealing with this for about 6 months now, and what I have found is that individual responses really do vary. That said, the general consensus on Marathon PR after 80 lbs seems solid.

What specifically worked for me: starting with a lower dose and titrating slowly. I would suggest MikeNYC_runner try the same approach and reporting back.

26 8dave_SLC, FDA_TrackerJim, ricardo_MIA and 23 others
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BiostatsBrad
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Durham, NC
Feb 27, 2026 at 5:01 PM#3

PeptideChemSF nailed it. Building on that — Marathon PR after 80 lbs weight is something I discuss with my dietitian regularly, and their clinical perspective aligns with what PeptideChemSF described.

One thing I would add: discussing this with your provider early helps.

49 0FranDenver, Dr.BariatricHTX, LindaRN_retired and 46 others
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SurmountFan_IN
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May 2024
Indianapolis, IN
Feb 27, 2026 at 5:18 PM#4

Subscribing to this thread. Marathon PR after 80 lbs is exactly what I've been researching. 🙏

Last edited: Feb 27, 2026 at 6:18 PM
33 6rachel_ABQ, traveltech_sara, AttorneyGrant and 30 others
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traveltech_sara
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Jan 2025
Remote, USA
Feb 27, 2026 at 5:35 PM#5

Clinical perspective on Marathon PR after 80 lbs weight loss :

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

34 5BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 31 others
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