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Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionHas anyone dealt with resistance training prevents 73% lean mass loss on semaglutide? Page 2

Has anyone dealt with resistance training prevents 73% lean mass loss on semaglutide?

SaraMom3 Fri, Aug 1, 2025 at 6:43 PM 11 replies 1,220 viewsPage 2 of 3
LipidDoc_ATL
Senior Member
1,123
5,678
Apr 2024
Atlanta, GA
Aug 1, 2025 at 9:33 PM#6
I know I benefited from "newbie gains" since I hadn't lifted seriously in ~20 years.

This is honest and important context. The lean mass gain you're seeing is partly muscle memory (satellite cell-mediated re-growth of previously trained fibers) and partly true newbie gains. A trained individual in the same situation would not see 5 lbs of lean gain during a 40-lb weight loss.

But here's the thing: most people starting GLP-1 therapy AREN'T trained. So your results ARE representative of what an untrained or detrained person can achieve if they commit to resistance training from day one. That's the message worth amplifying.

44 6rachel_ABQ, traveltech_sara, AttorneyGrant and 41 others
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pete_RVA
Member
178
890
Dec 2024
Richmond, VA
Aug 1, 2025 at 9:50 PM#7

Those deadlift numbers at 55... respect. I'm 34 and can barely pull 200. Time to stop making excuses.

40 23Dr.Martinez, mike_mod, SarahChen_PharmD and 37 others
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mark_tokyo
Member
456
1,890
Jun 2024
Tokyo, JP
Aug 1, 2025 at 10:07 PM#8

Ha, thanks. And honestly, the best part isn't the numbers on the bar — it's how I FEEL. I move differently. I stand up straighter. My lower back doesn't ache anymore. I carried all the groceries in one trip last week and my wife looked at me like I was showing off (I was). At 55, I feel physically better than I did at 40. That's not an exaggeration.

22 19LibrarianMeg, bri_stats, pete_manc_UK and 19 others
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