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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementTMI but the constipation is REAL Page 2

TMI but the constipation is REAL

NauseaFreeNow Tue, Jan 20, 2026 at 1:00 PM 37 replies 1,223 viewsPage 2 of 8
Dr.BariatricHTX
Senior Member
1,456
7,234
Feb 2024
Houston, TX
Jan 20, 2026 at 3:50 PM#6

Glad it resolved. A few additional points for everyone reading this later:

When constipation on GLP-1s requires medical attention:

  • No BM for 7+ days despite OTC interventions
  • Severe abdominal pain or distension
  • Vomiting (could indicate obstruction)
  • Blood in stool or rectal bleeding
  • Fecal impaction symptoms (constant urge, inability to pass, leaking of liquid stool around impaction)

Also — and I say this gently — make sure you're actually eating enough. Some patients get so focused on appetite suppression that they're consuming <800 calories and barely any fiber. Your colon needs bulk to work with. Even on a GLP-1, aim for 20-25g of fiber daily.

Last edited: Jan 20, 2026 at 9:50 PM
43 23CarlaRPh_TPA, steph_laguna, fiona_glasgow and 40 others
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hank_denver
Member
278
1,234
Sep 2024
Denver, CO
Jan 20, 2026 at 4:07 PM#7

Adding my two cents: a squatty potty (or any footstool that gets your knees above your hips) made a real difference for me. Changes the angle of the anorectal junction. Combined with Miralax it went from "impossible" to "manageable."

Also seconding the walking recommendation. On days I walk 30+ minutes, things move. On days I sit at my desk all day, nothing.

Last edited: Jan 20, 2026 at 8:07 PM
29 5raj_cambridge, ingrid_STO, pete_nash and 26 others
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HPLC_Greg
Senior Member
1,890
8,901
Feb 2024
Research Triangle, NC
Jan 20, 2026 at 4:24 PM#8

One more underrated tip: warm beverages. Hot coffee in the morning has a well-documented prokinetic effect on the colon. Even if the drug is slowing your GI tract, caffeine and the gastrocolic reflex from warm liquid can help kickstart things. I have a cup of hot coffee within 20 minutes of waking up and it's the most reliable part of my constipation management.

46 24RetaRick_CA, JenPlateau, SallyK_inj and 43 others
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