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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementTMI but the constipation is REAL Page 4

TMI but the constipation is REAL

NauseaFreeNow Tue, Jan 20, 2026 at 1:00 PM 37 replies 1,223 viewsPage 4 of 8
wei_SG
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Singapore, SG
Jan 20, 2026 at 6:40 PM#16

Congrats gary_naperville!! Keep going — you're doing incredible. 🎉

46 4WendyG_ATL, SaraMom3, Dr.MetabolicMD and 43 others
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patPC_UT
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Nov 2024
Park City, UT
Jan 20, 2026 at 6:57 PM#17

NauseaFreeNow's experience with TMI but the constipation resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I had more GI issues initially. But the overall trajectory has been remarkably similar. Down 65 lbs in 10 months.

One thing I would add that NauseaFreeNow did not mention: insurance coverage was a major hurdle.

9 12mike.trainer_LA, sarah_nash92, FitDadDave and 6 others
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Dr.Martinez
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Nov 2023
Boston, MA
Online
Jan 20, 2026 at 7:14 PM#18

Bookmarked 📌 The TMI but the info in this thread is essential. Coming back to this for sure.

Last edited: Jan 21, 2026 at 12:14 AM
26 9rachel_ABQ, traveltech_sara, AttorneyGrant and 23 others
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Dr.AddMedPHL
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Mar 2024
Philadelphia, PA
Jan 20, 2026 at 7:31 PM#19

Clinical perspective on TMI but the constipation is REAL:

I have managed over 200 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

40 12TomFromTexas, mike.trainer_LA, sarah_nash92 and 37 others
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SleepDoc_PDX
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Sep 2024
Portland, OR
Jan 20, 2026 at 7:48 PM#20

Subscribing to this thread. TMI but the constipation is exactly what I've been researching. 🙏

15 23mel_PDX, Dr.AddMedPHL, newstart_MO and 12 others
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